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A peer-reviewed study in the Journal of Endocrinology confirming that AOD9604 produces lipolysis and increases fat oxidation in obese mice via the beta-adrenergic pathway, with effects comparable to full-length HGH but without the insulin-disrupting side effects provided early mechanistic validation that informed the human trials

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For example, increased levels of the Egr gene were observed at 1 h, Nos , Srf , and Kras genes demonstrated increased expression at 1 and 24 h in all vessels, and Egr expression was increased at 24 h in both ovarian veins